Journal of Sasang Constitutional Medicine
  • pISSN: 1226-4075
  • eISSN: 2287-786X
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CURRENT ISSUE
Title
Clinical Study on Nonalcoholic Fatty Liver Disease Related Factors: Tumor Marker, Heart Rate Variability, Sasang Constitution
Authors
Si-Ra Gwak1, Lei Shen 1, Soo-Jung Park 2, Young-Mi Kwon 3, Jong-Cheon Joo 1
Affiliations
1 Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Wonkwang University
2 Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Woosuk University
3 Dept. of Radiology, College of Korean Medicine, Wonkwang University
Source
JSCM
Year
2019
Volume
31
Issue
2
Page
22-30
Information
Received
June 14, 2019
Revised
June 14, 2019
Accepted
June 25, 2019
DOI
https://doi.org/10.7730/JSCM.2019.31.2.
C.author
Jong-Cheon Joo (jcjoo@wku.ac.kr) 
Published
June 30, 2019
Abstract
Objectives
The aim of this study is to investigate the related factors of nonalcoholic fatty liver disease (NAFLD).
Methods
The subjects were 187 persons diagnosed as fatty liver by abdominal ultrasonography. They were divided into three groups according to the severity of fatty liver: control, mild, moderate or severe. The three groups' general characteristics, laboratory results, liver function indexes, metabolic syndrome indexes, tumor markers, heart rate variability values and Sasang constitution distribution were compared and analyzed.
Results
Male ratio, height, weight, body mass index, red blood cell count, hemoglobin level and creatinine level were higher in NAFLD groups than in control group. The levels of sodium and amylase were higher in control than in NAFLD. In liver function, the levels of aspartate transaminase, alanine transaminase and gamma-glutamyl transpepsidase of NAFLD were higher. In metabolic syndrome index, systolic blood pressure, diastolic blood pressure, waist circumference, total cholesterol, triglyceride and low density lipoprotein cholesterol levels were higher in NAFLD, while high density lipoprotein cholesterol level was higher in control. The alpha-feto protein level was higher in NAFLD, and the heart rate variability was not different between NAFLD and control groups. In Sasang constitution, Taeeumin ratio of NAFLD was higher than of control.
Conclusions
The results suggest that nonalcoholic fatty liver is clinically related to liver dysfunction, metabolic syndrome, tumor markers, and Sasang constitution. Further studies are needed to control nonalcoholic fatty liver disease and prevent severe disease such as cirrhosis and cancer caused by fatty liver.
Keyword
nonalcoholic fatty liver disease, related factor, alpha-feto protein, heart rate variability, Sasang constitution, metabolic syndrome
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